However, these benefits are often lost due to weight regain (9), which is very frequent among patients undergoing massive WL (10). In addition, the improvement in total testosterone (TT) level is quite limited and not sufficient to reach the target level (usually mid-range of normal ~500 ng/dL) (11). One possible alternative approach is the use of aromatase inhibitors (AI) to inhibit the conversion of androgens into estrogens, thereby interrupting the cycle of the estrogen-induced inhibition of the hypothalamic-pituitary-gonadal axis. Testosterone increase and estradiol (E2) reduction have been reported in hypogonadal men treated with AI (6, 12–16). However, only a limited number of studies have investigated the effect of AI therapy on clinical outcomes; thus, the safety and efficacy on the use of AIs in men with obesity-induced HHG remains largely undetermined (6, 12–18). Because WL remains the standard of care in obesity, we designed this proof-of-concept study to determine the efficacy and safety of the combination of WL plus AI in severely obese men with HHG.
In postmenopausal women, estrogen replacement reduces the risk of type 2 diabetes mellitus (6). Estrogens are generated from substrate androgens through the action of the cytochrome P450 enzyme aromatase (7). It is possible that the metabolic phenotype in androgen-deficient men is largely a consequence of downstream estrogen deficiency. Low levels of testosterone, a natural hormone produced in the body, can lead to hair loss, weight gain, a decrease in sex drive, and many other unwanted side effects. The use of an aromatase inhibitors, (Arimidex or Anastrozole) can stop this conversion and breakdown of testosterone. Arimidex has been used in coordination with TRT in many men’s health testosterone clinics to reduce the breakdown of testosterone, reduce estrogen production and as a treatment for gynecomastia.
Severe impairments in spermatogenesis may be seen and may be permanent depending on the duration and potency of agents used. At present time his T level is 170 ng/dL and his LH and FSH are low at 1.5 (UNITS). Upon physical examination, the testes have mild atrophy and his overall physique is still muscular. In our first case-based scenario, a 38-year-old hypogonadal male patient has severely abnormal semen analyses as a result of use of testosterone therapy.
Body composition, precisely the amount of adipose tissue, can influence estrogen levels, affecting how much Anastrozole may be needed to maintain hormonal balance. For men with naturally low levels of testosterone, combining Anastrozole with replacement therapy can bring about a more balanced hormonal profile, improving overall well-being. Arimidex is also suitable for men with hypogonadism and obesity, as the excess adipose tissue increases the aromatization.
During your Arimidex treatment, consider keeping notes on any side effects you’re having. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. Your doctor may monitor your liver function throughout Arimidex treatment to check for liver problems.
Despite this, it can take some time for the concentration of the drug to build up in the blood plasma to reach the peak level, which can take about a week. Despite this, impressive amounts of estrogen level reduction have been noted in studies on the use of Arimidex in women at the medical dosage of 1mg daily, with a 70% reduction within just 24 hours. Circulating estrogen levels remained this low for up to 6 days after the last dosage of Arimidex.
By inhibiting the aromatase enzyme and slowing the production of estrogen, this drug helps prevent gynecomastia. That’s because estrogen is to the breast tissue as gasoline is to your car. Aromatase inhibitors can also have significant effects on sexual health and reproductive function in men.
Of course, it also goes without saying that the more severe reduction of Estrogen, the more severe the cardiovascular impacts will be in this area. Studies have demonstrated that Arimidex use results in the increased incidence and probability of experiencing bone fractures. Although this https://goldeneaglefreight.com/steroids-understanding-their-uses-benefits-and-18/ is a more female-specific side effect of Arimidex use, Estrogen does play an important role in the promotion and retention of bone mineral content in males as well. There have been studies conducted that discovered that Arimidex does negatively impact calcium turnover levels in bone tissue with even short term use. Aside from the use in bodybuilders, Arimidex has also been medically used in males as well6.
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